منابع مشابه
C-40 Truncated carbocyclic formycin derivatives
Formycin is a naturally occurring C-glycoside (C-nucleoside) that possesses antitumor, antibacterial, antifungal, and antiviral activity. In connection with our ongoing interest in the design and syntheses of C-nucleoside derived antiviral agents this report describes the preparation of carbocyclic formycin and its 7-hydroxy (oxo) analog lacking the C-40 hydroxylmethylene moiety in racemic form...
متن کاملA short and novel synthesis of carbocyclic nucleosides and 4 0-epi-carbocyclic nucleosides from 2-cyclopenten-1-ones
Carbocyclic nucleoside analogues remain interesting target molecules having the potential to combine biological activity with greater metabolic stability than their sugar counterparts. This paper describes a rapid and versatile synthetic approach to such compounds based on commercial cyclopentenones (e.g., 1) that has been developed in our laboratory. Carbocyclic nucleosides like 2 0-methylaris...
متن کاملBiosynthesis of the formycin family.
The formycin family is composed of the G-ribosides of pyrazolopyrimidine derivatives1'^. In a previous paper we proposed a scheme for their biosynthesis in Nocardia interforma as follows :? ->formycin B monophosphate (FMBP)-» formycin A monophosphate (FMAP) -> formycin A (FMA) -* formycin B (FMB) -> oxoformycin B3). This schemeonly explains the terminal steps of the biosynthetic pathway while t...
متن کاملMetabolic conversion of formycin B to formycin A and to oxoformycin B in Nocardia interforma.
A strain of Nocardia interforma having low productivity of formycin A was selected. Washed cells of this strain convert formycin B to oxoformycin B (reaction I), while those of the original strain collected during formycin A producing phase convert formycin B to formycin A (reaction II). Reaction I is inhibited by allopurinol, an inhibitor of xanthine oxidase. Reaction II is inhibited by hadaci...
متن کاملCarbocyclic Sinefungin.
(3aS,4S,6R,6aR)-Tetrahydro-2,2-dimethyl-6-vinyl-3aH-cyclopenta[d][1,3]-dioxol-4-ol, itself available from ribose, provided a convenient entry point for an 18-step preparation of carbocyclic sinefungin. This procedure is adaptable to a number of carbocyclic sinefungin analogs with diversity of heterocyclic base and in the amino acid bearing side chain.
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2008
ISSN: 0040-4020
DOI: 10.1016/j.tet.2007.10.054